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Journal of Research in Medical Sciences، جلد ۱۶، شماره ۱، صفحات ۹۴-۰
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عنوان انگلیسی Interleukin-4 and interferon- γ levels in Epstein-Barr virus-associated infectious mononucleosis and nasopharyngeal carcinoma
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} BACKGROUND : Cytokines have been suggested to participate in the pathogenesis of infectious mononucleosis (IM) and nasopharyngeal carcinoma (NPC). METHODS: Serum levels and gene expression of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were assessed by immunologic and PCR assays, respectively in patients with Epstein-Barr virus (EBV)-associated IM and NPC and EBV negative controls. RESULTS: The serum levels of IFN- γ were elevated, but those of IL-4 were decreased in IM and NPC patients as compared with those of the control group (p < 0.05). CONCLUSIONS: These results suggest that serum levels of IFN- γ may be predominant over those of IL-4 during the course of IM and NPC. KEYWORDS: Interferon-Gamma, Interleukin-4, Infectious Mononucleosis, Nasopharyngeal Neoplasms .
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نویسندگان مقاله dyah r budiani | dyah r budiani
lecturer, immunology unit, department of pathology, school of medicine, sebelas maret university, surakarta


sofya m haryana | sofya m haryana
professor, department of histology and cell biology, school of medicine, gadjah mada university, yogyakarta


wihaskoro sosroseno | wihaskoro sosroseno
professor, school of dentistry, aimst university, semeling, bedong, kedah
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/5225
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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