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Journal of Research in Medical Sciences، جلد ۱۵، شماره ۶، صفحات ۲۹۹-۰
عنوان فارسی
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عنوان انگلیسی Are there any differences between features of proteins expressed in malignant and benign breast cancers?
چکیده انگلیسی مقاله Normal 0 false false false MicrosoftInternetExplorer4 BACKGROUND: The most common cancer among women is breast cancer and it has been blamed as the second leading cause of cancer death in women; so far many approaches have been used to analyze and detect benign and malignant forms of cancer and understanding the features involved in proteins expressed by various types of breast cancers is crucial. METHODS: Herein features of proteins expressed in malignant, benign and both cancers were compared using different screening techniques, clustering methods, decision tree models and generalized rule induction (GRI) algorithms to look for patterns of similarity in two benign and malignant breast cancer groups. RESULTS: The findings showed that the N-terminal amino acid was Met and 57 out of 838 proteins' features ranked as important (p > 0.05). The depth of the trees induced by tree induction models varied from 5 (in the Quest model) to 2 (in the C5.0 model) branches. The best performance evaluation found when C&RT model applied and the worst evaluation found when CHAID model applied. No significant difference in the percentage of correctness, performance evaluation, and mean correctness in tree induction algorithms was found when feature selection applied on datasets, but the number of peer groups reduced significantly (p < 0.05) when feature selection model applied. CONCLUSIONS: The frequency of Ile-Ile was the most important protein attributes in all tree and rule induction models. The importance of sequence-based classification and the frequency of Ile-Ile in prediction of malignant and benign breast cancer have been discussed here. KEYWORDS: Bioinformatics, Modeling, Breast Cancer, Malignant, Benign.
کلیدواژه‌های انگلیسی مقاله Bioinformatics, modeling, breast cancer, malignant, benign
نویسندگان مقاله منصور ابراهیمی | mansour ebrahimi
bioinformatics research group, green research center, qom university, qom, iran.

سازمان اصلی تایید شده: دانشگاه قم (Qom university)

اسماعیل ابراهیمی | esmaeil ebrahimie
department of crop production and plant breeding, college of agriculture, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نرگس شم آبادی | narges shamabadi
member of young researcher club, islamic azad university of qom, qom, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهدی ابراهیمی | mahdi ebrahimi
department of informatics, saarland university, saarbrucken, germany.
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/4622
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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