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Journal of Research in Medical Sciences، جلد ۱۵، شماره ۳، صفحات ۱۵۰-۰
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عنوان انگلیسی Serum lipid profiles in patients with beta-thalassemia major and intermedia in southern Iran
چکیده انگلیسی مقاله BACKGROUND: Beta-thalassemia is considered to be the most frequent hereditary blood disorder worldwide. Lipid abnormalities have been detected in different types of beta-thalassemia . The aim of this study is to assess the lipid profiles in beta-thalassemia major (BTM) and beta-thalassemia intermedia (BTI) patients in southern Iran. METHODS: The study group consisted of 55 BTM patients and 50 BTI patients. The control group included 130 sex- and age-matched healthy participants. Serum lipids profiles (total cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol) as well as hemoglobin (Hb) and ferritin, were compared between the three groups. P value < 0.05 was considered statistically significant. RESULTS: There were no significant differences between BTM and BTI patients regarding age or sex. Mean triglyceride concentration was not significantly different between patients and controls. Total cholesterol and LDL-cholesterol were significantly lower in patients with BTM and BTI in comparison with controls (p < 0.001). HDL-cholesterol was significantly lower in patients with BTI than in controls (p < 0.03). CONCLUSIONS: In patients with BTM and BTI, total cholesterol and LDL-cholesterol were lower than in control participants. The mechanisms that may account for these findings are increased erythropoiesis and cholesterol consumption in BTI, and iron overload and oxidative stress in BTM. KEYWORDS: Beta-Thalassemia Major, Beta-Thalassemia Intermedia, Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol, Triglycerides. Normal 0 false false false MicrosoftInternetExplorer4
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نویسندگان مقاله سزانه حق پناه | sezaneh haghpanah
hematology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مریم دوانی | maryam davani
hematology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

بهرنگ صمدی | behrang samadi
hematology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

افسانه اشرفی | afsaneh ashrafi
a hematology research center, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مهران کریمی | mehran karimi
prof. of pediatric hematology ,hematology research center
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/3871
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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