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Journal of Research in Medical Sciences، جلد ۱۵، شماره ۲، صفحات ۸۴-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Using functional Magnetic Resonance Imaging to differentiate between Healthy Aging subjects, Mild Cognitive Impairment, and Alzheimer’s Patients
چکیده انگلیسی مقاله BACKGROUND: Alzheimer's disease is the most common form of dementia which is still difficult to be differentiated from other types of brain disorders. Moreover, Mild Cognitive Impairment refers to the presence of cognitive impairments that is not severe enough to meet the criteria of Alzheimer's, and its diagnosis in early stages is so critical. There is currently no distinct method available for diagnosing Alzheimer's or Mild Cognitive Impairment, and their diagnosis needs a combination of different methods and assessments. METHODS: The aim of this study was to evaluate the effectiveness of functional Magnetic Resonance Imaging (fMRI) in differentiating between Alzheimer's, Mild Cognitive Impairment (MCI) and healthy aging. To prove fMRI's ability, resting-state brain activation patterns between these three groups of subjects were compared using Independent Component Analysis (ICA) algorithm. Forty age- and sex-matched subjects, 15 elderly, 11 MCI and 14 Alzheimer's subjects were examined. RESULTS: The results showed that during a certain resting-state session, healthy aging brain benefits from larger area and greater intensity of activation (compared with MCI and Alzheimer's group) in Posterior Cingulate Cortex (PCC) region of the brain, as part of Default Mode Network. CONCLUSIONS: This difference in activation pattern can be used as a diagnostic criterion in using fMRI for differentiating between Alzheimer's Disease (AD), MCI and healthy aging. KEYWORDS: FMRI, Default Mode Network, Alzheimer's, Mild Cognitive Impairment, Resting-State. Normal 0 false false false MicrosoftInternetExplorer4
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نویسندگان مقاله محمد علی عقابیان | mohammad ali oghabian
head of neuroimaging and analysis team niat


سید امیر حسین بتولی | seyed amir hossein batouli
radiation medicine engineering department of shahid beheshti university

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

مریم نوروزیان | maryam noroozian
memory and behavioral neurology department of tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم ضیایی | maryam ziaei
psychology department of shahid beheshti university

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

هژیر هژیر | hajir sikaroodi
department of neuro-vascular diseases, shariati hospital, tehran
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/3942
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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