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Journal of Research in Medical Sciences، جلد ۱۵، شماره ۱، صفحات ۱۴-۰
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عنوان انگلیسی The predictive role of histopathological findings in renal insufficiency and complete remission in a sample of Iranian adults with primary focal segmental glomerulosclerosis
چکیده انگلیسی مقاله BACKGROUND: Primary focal segmental glomerulosclerosis (FSGS) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (SS). The aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in Iranian adults with primary focal segmental glomerulosclerosis. METHODS: In this historical cohort study, pathological findings of 50 patients with primary FSGS were reviewed by single renal pathologist without knowing about patients' identities or outcomes. Patients were divided based on their histopathological findings and outcomes were compared among these groups. RESULTS: There were significant differences in the complete remission rate in subjects with and without mesangial hypercellularity (p < 0.05), and in patients with and without hyalinosis (p < 0.05). According to the cut off points based on ROC curve analysis for the quantitative data, there was significant difference in renal insufficiency between the patients with and without global scars more than 12% (p < 0.05). Also multiple logistic regression analysis strongly suggests the association of mesangial hypercellularity and global scar with no complete remission and progression to renal insufficiency, respectively. CONCLUSIONS: In the studied patients, presence of mesangial hypercellularity and hyalinosis has been suggested as prognostic factors for lower remission rate. According to multivariate analysis, only mesangial hypercellularity and global scar were found to act as independent prognostic predictors of lower complete remission rate and progression to renal insufficiency in patients with FSGS, respectively. KEYWORDS: Focal Segmental Glomerulosclerosis, Mesangial Hypercellularity, Hyalinosis, Global Scar, Renal Insufficiency, Remission. Normal 0 false false false MicrosoftInternetExplorer4
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نویسندگان مقاله دیانا طاهری | diana taheri
department of pathology, isfahan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی چهریی | ali chehrei
department of pathology, isfahan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

پرگل samanianpour | pargol samanianpour
medical students research committee, school of medicine, isfahan university of medical sciences, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهره صدرارحامی | shohreh sadrarhami
medical students research committee, school of medicine, isfahan university of medical sciences, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

عمار حسن زاده کشتلی | ammar hassanzadeh keshteli
medical students research committee, school of medicine, isfahan university of medical sciences, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهرزاد شهیدی | shahrzad shahidi
division of nephrology, department of internal medicine, isfahan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/3099
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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