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Journal of Research in Medical Sciences، جلد ۱۴، شماره ۶، صفحات ۳۷۵-۰
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عنوان انگلیسی P63 and Ki-67 expression in trophoblastic disease and spontaneous abortion
چکیده انگلیسی مقاله Normal 0 false false false MicrosoftInternetExplorer4 BACKGROUND : Despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. The aim of this study was to evaluate the value of two immunohistochemical markers in the differential diagnosis of subgroups of lesions of villous trophoblasts and spontaneous abortions. METHODS : Immunohistochemistry with the P63 and Ki-67 antibody was performed in formalin-fixed paraffin-embedded samples of non hydropic abortion (n = 14), partial hydatidiform mole (n = 12), complete hydatidiform mole (n = 12) and choriocarcinoma (n = 12). The Ki-67 and P63 labeling index (number of positive nuclei/total number of nuclei) for villous stromal cells, cytotrophoblasts and syncytiotrophoblasts were evaluated separately by counting 100 cells of each population. Statistical analysis was carried out by χ2 analysis, and the Mann-Whitney U test. Statistical significance was determined at p < 0.05 on the basis of 2-tailed tests. RESULTS : None of nonhydropic spontaneous abortions analyzed exhibited positive cytotrotrophoblastic and syncytiotrophoblastic cells for P63. The syncytiotrophoblastic cells were negative for p63 in all of choriocarcinomas. All of choriocarcinomas analyzed exhibited severe expression of Ki-67 in cytotrotrophoblastic cells. None of abortions and partial moles was diffusely labeled with Ki-67. CONCLUSIONS : Ki-67 labeling index in cytotrophoblastic cells is the best index to differentiate between abortion and subgroups of lesions of villous trophoblasts as well as between different subgroups of lesions of villous trophoblasts. Ki-67 is a better marker than P63 to attain this goal. KEYWORDS : Partial Hydatidiform Mole, Complete Hydatidiform Mole, Choriocarcinoma, Abortion, P63, Ki-67, Immunohistochemistry.
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نویسندگان مقاله مینو erfaniana | minoo erfaniana
resident of anatomoclinical pathology, mashhad medical university, mashhad, iran.


نوریه شریفی | nourieh sharifi
associate professor of anatomoclinical pathology, mashhad medical university, mashhad, iran


عباس علی omidic | abas ali omidic
professor of anatomoclinical pathology, mashhad medical university, mashhad, iran.
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/3583
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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