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Journal of Research in Medical Sciences، جلد ۱۴، شماره ۴، صفحات ۲۳۹-۰
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عنوان انگلیسی Clinicopathological significance of E-cadherin, !-catenin and p53 expression in gastric adenocarinoma
چکیده انگلیسی مقاله BACKGROUND : E-cadherin/catenin complexes exert a role in cell adhesion. ' -catenin is a key player in Wnt signaling pathway in gastric cancer. P53 is a tumor suppressor gene which also regulates apoptosis. We assessed the expression of E-cadherin, ' -catenin and p53 in gastric adenocarcinoma, and their correlations with linicopathological features. METHODS : Fifty six formalin-fixed, paraffin-embedded archival specimens of gastric adenocarcinoma were andomly included as cases. Adjacent tumor-free gastric mucosa of different premalignant stages was obtained from the cases. Immunohistochemical staining was performed to assess E-cadherin, ' -catenin and p53 expression. RESULTS : All chronic atrophic gastritis and intestinal metaplasia revealed normal membranous staining. Only one patient with dysplasia had abnormal expression of E-cadherin and ' -Catenin. Abnormal E-cadherin, ' -catenin and p53 expression was found in 50%, 48.2% and 76.8% of cancer specimens respectively. Abnormal expression of E-cadherin was significantly correlated with aberrant ' -catenin expression. Abnormal E-cadherin and ' -catenin expression were significantly correlated with depth of tumor invasion and advanced gastric cancer (p ' -catenin. P53 was not associated with clinicopathological variables. CONCLUSIONS : Abnormal expression of the E-cadherin and ' -catenin were associated with each other and influenced by histogenesis of gastric cancer and malignant behavior of tumor but not significant in premalignant lesions. They are more frequent in diffuse type and associated with advanced gastric cancer. P53 alterations are more frequent in the Iranian population compared with others. KEYWORDS : Gastric Cancer, E-cadherin, ' -catenin, p53, Immunohistochemistry.
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نویسندگان مقاله دکتر محمدرضا زالی | mohammad reza zali
research center for gastroenterology and liver disease rcgln , shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

omeed معاون | omeed moaven
division of human genetics, immunology research center, avicenna research institute


حمید رضا اسدزاده عقدایی | hamid reza asadzadeh aghdaee


کامران غفارزادگان | kamran ghafarzadegan
department of pathology, omid hospital, mums, mashhad, iran


خدیجه جامی احمدی | khadijeh jami ahmadi
division of human genetics, immunology research center, avicenna research institute


مهدی فرزادنیا | mehdi farzadnia
department of pathology, imam-reza hospital, mums, mashhad, iran


رضا ابراهیم زاده | reza ebrahimzadeh


آزاده arabib | azadeh arabib
division of human genetics, immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد رضا عباس زادگان | mohammad reza abbaszadegan
division of human genetics, immunology research center, avicenna research institute
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2400
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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