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Journal of Research in Medical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۱۱-۰
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عنوان انگلیسی The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran
چکیده انگلیسی مقاله BACKGROUND : To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran. METHODS : During a 4-year period (2003 to 2007), 55 children (33 male and 22 female) diagnosed with ALL at Unit of Hematology/ Oncology, Department of Pediatrics, Isfahan University of Medical Science, were enrolled in this crosssectional study. Metabolic syndrome was defined using the modified version of Adult Treatment Panel (ATP III) criteria. Insulin resistance was defined based on the homeostasis model assessment index (HOMA-IR). RESULTS : The mean age of participates was 10.4 years (range 6-19 years) and the mean interval since completion of chemotherapy was 35 months. Twenty percent (11/55) of survivors (10 male, 1 female) met criteria for diagnosis of metabolic syndrome. Obesity was observed in one forth of patients and nearly 3/4 of obese patients had metabolic syndrome. High serum insulin levels were found in 16% of participants and in 63% of obese survivors. The mean insulin levels in survivors with metabolic syndrome was three-times more than those without (28.3 mu/l vs. 9.57 mu/l, p = 0.004). Insulin resistance was detected in 72.7% of survivors with metabolic syndrome and it was ositively correlated with serum triglycerides (0.543, p CONCLUSIONS : The prevalence of metabolic syndrome in survivors of childhood leukemia in Iran is higher than developed countries. Nearly all of the obese patients had metabolic syndrome. Weight control and regular physical exercise are recommended to the survivors. KEYWORDS : Acute lymphoblastic leukemia, metabolic syndrome, obesity, children.
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نویسندگان مقاله ناهید رییسی | nahid reisi
assistant professor of pediatrics, pediatric hematologist, pediatric hematology department, al-zahra hospital, isfahan, iran.


افشین آژیر | afshin azhir
md, department of pediatrics, isfahan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مهین هاشمی پور | mahin hashemipour
professor of pediatrics, pediatric endocrinologist, department of pediatric, al-zahra hospital, isfahan, iran.


پوران رییسی | pouran raeissi
phd in statistics and measurements, school of management and medical information sciences, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

عباسقلی امینی | abasgholi amini
assistant professor of pediatrics, department of pediatric, al-zahra hospital, isfahan, iran.


علیرضا معافی | alireza moafi
associate professor of pediatrics, pediatric hematologist, pediatric hematology department, saied al-shohada hospital, isfahan, iran.
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2554
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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