این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۴، شماره ۱، صفحات ۱۹-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of Baicalin on inflammatory mediators and pancreatic acinar cell apoptosis in rats with sever acute pancreatitis
چکیده انگلیسی مقاله BACKGROUND : To investigate the effects of Baicalin and Octreotide on inflammatory mediators and pancreatic acinar cells apoptosis of rats with severe acute pancreatitis (SAP). METHODS : SD rats were randomly divided into sham operated group (I group), model control group (II group), Baicalin treated group (III group) and Octreotide treated group (IV group). Each group was also divided into subgroup of 3, 6 and 12 h (n = 15). The mortality rate, ascites/body weight ratio as well as the level of endotoxin, NO and ET-1 in blood were measured. The pathological severity score of pancreas, apoptotic indexes, and expression levels of Bax and Bcl-2 proteins in each group were investigated. RESULTS : The survival rate of III and IV group has a significant difference compared with II group (P12 h CONCLUSIONS : Compared with Octreotide in the treatment of SAP, the protective mechanisms of Baicalin include reducing the excessive inflammatory mediators’ release, inducing the pancreatic acinar cells apoptosis. KEY WORDS : Severe acute pancreatitis, baicalin, octreotide, inflammatory mediators, apoptosis, tissue microarrays.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله زانگ xiping | zhang xiping
department of general surgery, hangzhou first people’s hospital, hangzhou 310006,zhejiang province, china


tian hua | tian hua
department of general surgery, second affiliated hospital of zhejiang university school of medicine , hangzhou 310009, zhejiang province, china


chen hanqing | chen hanqing
zhejiang university of traditional chinese medical, hangzhou 310053,zhejiang province, china


chen li | chen li
department of general surgery, second affiliated hospital of zhejiang university school of medicine , hangzhou 310009, zhejiang province, china


yu binyan | yu binyan
zhejiang university of traditional chinese medical, hangzhou 310053,zhejiang province, china


ma جینگ | ma jing
zhejiang university of traditional chinese medical, hangzhou 310053,zhejiang province, china
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2184
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات