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Journal of Research in Medical Sciences، جلد ۹، شماره ۶، صفحات ۲۷۰-۰
عنوان فارسی
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عنوان انگلیسی The Effect of EDTA and Garlic Extract Combination on Plasma Lipids, Lipoporteins, and Fatty Streaks in Cholesterol Fed Male Rabbit Aorta
چکیده انگلیسی مقاله Background: Garlic extract is used in treatment of hypercholesterolemia, although its efficacy isn’t exactly clear. There is a little information about mechanism of garlic effect on plasma lipids. By intervention of garlic in atherogenesis process it has been shown that it has a protective effect against cardiovascular disease. On the other hand, it has been shown that EDTA (Ethylene Diamin Tetra Acetic Acid) improves blood flow and decreases the vascular atherosclerotic symptoms. Methods: The objective of this study was to evaluate the effect of EDTA and garlic extract with together on plasma concentration of cholesterol, Triglyceride, LDL, and HDL, and formation of fatty streaks through the phenomena called “chelation therapy” in male Rabbit aorta. 32 male Rabbits were used and divided to 4 groups as group 1: cholesterol – rich diet (CRD) + EDTA + Garlic Extract (GE), group 2: CRD + EDTA, Group 3: CRD + GE, Group 4: CRD (control group). The animals were under food and drug diet for 5 weeks. Blood samples of Rabbits were taken before and after the test and then plasma cholesterol, triglyceride, LDL and HDL were measured. Finally, abdominal aorta was studied and pathologically evaluated. Results: The experiments showed the significant decrease of mean cholesterol in case groups and mean triglyceride in the groups which have received EDTA + GE and EDTA. Our results showed that mean LDL and LDL/HDL Ratio in case groups have been decreased in comparison to control group. In addition, there was a significant increase in mean HDL in the group which has received EDTA + GE. Conclusion: In this study it was shown that the using of fresh garlic and EDTA with together has a reductive effect on cholesterol, Triglyceride, and LDL concentration and also has an increasing effect on HDL concentration. But it seems that concomitant using of these tow substances with together strengthen the effect of each one, and it produces a great reduction of the blood lipids concentration.
کلیدواژه‌های انگلیسی مقاله atherosclerosis, garlic, EDTA.
نویسندگان مقاله m r شریفی | m r sharifi
department of physiology, medical school, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

s جاودان | s javdan
department of physiology, medical school, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

m فشارکی | m fesharaki
department of physiology, medical school, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/931
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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