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Journal of Research in Medical Sciences، جلد ۹، شماره ۴، صفحات ۱۷۳-۰
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عنوان انگلیسی Pretreatment Plasminogen Activator Inhibitor-1 (PAI-1) Level in the Failure of Streptokinase Therapy in Acute Myocardial Infaction
چکیده انگلیسی مقاله Background: The risk for unsuccessful reperfusion after streptokinase therapy may be caused by the antifibrinolytic effect of platelet-derived type 1 plasminogen activator inhibitor (Pal-1) and antistreptokinase antibodies. This study aims to show the relation of pretreatment PAI-1 levels of patients with acute myocardial infarction treated with streptokinase and the outcome of fibrinolysis, emphasizing on reperfusion with and without considering pretreatment antistreptokinase antibodies. Methods: Pretreatment PAI-1 and antistreptokinase antibodies levels of 61 patients with acute myocardial infarction, treated with streptokinase, were determined by an enzyme- linked immunosorbent assay kit method. Failure of thrombolysis with streptokinase was present when reperfusion was unsuccessful as assessed by noninvasive reperfusion criteria. Results: Mean pretreatment PAI-1 level of patients was 29.72 ± 4.74 ng/ml. Thrombolysis with streptokinase failed significantly with higher pretreatment PAI-1 levels (p 25ng/l and antistreptokinase antibodies higher than normal levels in patients before the start of streptokinase therapy, candidates for potentially unsuccessful streptokinase therapy (with failed reperfusion) can be identified in advance and an alternative therapy such as primary angioplasty with better immediate results can be started.
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نویسندگان مقاله h شمیرانی | h shemirani
nour hospital, isfahan, iran.


m تاجمیرریاحی | m tajmirriahi
nour hospital, isfahan, iran.


عبدالمجید رضایی | a rezaei
nour hospital, isfahan, iran.


f oreisi | f oreisi
nour hospital, isfahan, iran.
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/911
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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