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Journal of Research in Medical Sciences، جلد ۸، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES
چکیده انگلیسی مقاله Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely elimination of combat trauma nightmares. This study prompted an open trial of prazosin for Iran & Iraq combat PTSD patients nightmares. Method: Twenty two male and married patients with chronic DSM N PTSD and combat trauma related nightmares participated in an 8-week Before - After open trial. The exclusion criteria included current substance abuse or dependency, psychotic disorders and any medical condition that contraindicated the use of prazosin. Results: Six patients were withdrown from the study because of Prazosin side effects. In reminders average of nightmare severity reduced from 6.75 to 3.56 which was statistically significant (p< 0.001). Dicussion & Conclusion: The association between prazosin administration and reduction of PTSD nightmare severity suggested possible efficacy of ?1- adrenergic recptor blockade for this PTSD symptom.
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نویسندگان مقاله g assadouahi | g assadouahi
department of psychiatry. noor medical center hasht behesht ave. isfahan


gh احمدزاده | gh ahmadzadeh
department of psychiatry. noor medical center hasht behesht ave. isfahan


j محمودی قرایی | j mahmoudi gharaei
department of psychiatry. noor medical center hasht behesht ave. isfahan


n بشردوست | n bashardoost
department of psychiatry. noor medical center hasht behesht ave. isfahan


t فقیهی | t faghihi
department of psychiatry. noor medical center hasht behesht ave. isfahan
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2891
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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