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Journal of Research in Medical Sciences، جلد ۸، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی THE RATE OF CLINICAL RESPONSE OF ORAL LOADING SODIUM VALPROATE IN ACUTELY MANLC PATIENT
چکیده انگلیسی مقاله Introduction: Acheiving accelerated clinical response is desirable in patients with acute manic episode. We conducted a prospective study to compare the rate of clinical response of oral loading sodium valproate versus standard dose titration. Methods: Fourty - two patients who met DSM - IV critevia for current manic episode and who had a "Young mania rating scale "score between 20 and 50 were randomly assigned on a double blind basis to recieve valproate oral "loading"(N = 21) at a dose of 20 mg/kg in divided doses for 7 days and valproate "non -loading" at a starting dose of 10 mg/kg followed by standard titration which at day 6 , they recieved 20 mg/kg valproate. Patients were scored at day 0, 3, 5 and 7 by a blindraterusing YMRS. Results: There was no significat differences between the groups in advers events and useing of adjunctive tranquilizer .The efficacy of valproate in both two groups was similar but " the rate of improvement on YMRS" over the first 3 days was significantly greater in loading group. Conclusion: Valproate oral loading with sodium valproate can induced a more rapid clinical response in acutely manic patient.
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نویسندگان مقاله k شفیعی | k shafiee
department of psychiatry, isfahan university of medical sciences and health services, isfahan, ira

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

m barekateyn | m barekateyn


n بشردوست | n bashardoost


j محمودی | j mahmoudi


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2910
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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