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Journal of Research in Medical Sciences، جلد ۸، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Scienc, Isfahan,Iran
چکیده انگلیسی مقاله The problem of carry-over effect in two period -two sequence cross-over studies has already brought about a lot of discussion and has induced to bring up different views and recommendations. The present study deals with relationship between carry-over effects and sample size in 2 x 2 cross-over design. It has been shown that when such effects exist, number of samples will differ from the case when there is no carry-over effect. The difference in sampel size has been estimated and has been shown that depends upon the differences in size and direction of carry-over effect and direct treatment effects. The influence of carry-over effects on power of the test also has been considered and its variation has been shown. The results suggest that while determining sampel size for a 2x2 cross-over study, it is matter of wise to take into account any knowledge about carry-over effect difference which is in hand from a previous or pilot study or even from a rational guess, especially if carry-over effects difference and direct treatment effects difference are in the same direction. Theoretical outcomes are used for a practical example and related results have been presented.
کلیدواژه‌های انگلیسی مقاله 2 x 2 cross-over study, Sample size, Carry-over effect
نویسندگان مقاله b سلیمانی | b soleymani
department of biostatistics and epidemiology, school of health, isfahan university of medical scienc, isfahan,iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

فقیه زاده | s faghihzadeh


انوشیروان کاظم نژاد | anoushiravan kazemnezhad


g h بابایی | g h babaei


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/2989
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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