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Journal of Research in Medical Sciences، جلد ۷، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی VITAMINE E IN THE MANAGEMENT OF DRUG INDUCED TARDIVE DYSKINESIA: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL
چکیده انگلیسی مقاله Introduction. Expresssion of tardive dyskinesia as one of the side effects of antipsychotic drugs causes various problems in psychotic patients. It is the main cause of patient"s drug incompliance.Vitamine E with it"s antioxidants properties might be an effective treatment for tardive dyskinesia. Methods. In a randomized double blind clinical trial, thirty inpatients of the psychiatric hospital in Isfahan were studied. Patients were stratified according to their age, psychiatric disorder and duration, intensity of tardive dyskinesia and antipsychotic dosage. Then they were asssigned randomly into two groups. Vitamine E (600 mg/day) was administered to interventional group (15 patients). Another group received placebo (15 patients). Treatment durated for 6 weeks. Abnormal Involuntary Movment Scale (AIMS) was used to measure tardive dyskinesia intensity. Results. Average of disorder intensity in those who received vit. E, dropped down from 8.33/10 (befor treatment) to 6.13/10 (after treatment). It means 26.3 percent reduction of tardive dyskinesia intensity. This difference was only 7.3 percent in control group. There were no statistical diffrence between two groups after treatment (P>0.05). Discussion. There is no statistical efficacy for vitamine E in the management of tardive dyskinesia. But it is recommended to make another study with more samples.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله m کار احمدی | m kar ahmadi
department of psychiatry, school of medicine, isfahan university of medical sciences and health services, isfahan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

f rajay | f rajay


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/3299
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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