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International Journal of Organ Transplantation Medicine، جلد ۷، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Natural Killer Cell Subsets and IL-2, IL-15, and IL-18 Genes Expressions in Chronic Kidney Allograft Dysfunction and Graft Function in Kidney Allograft Recipients
چکیده انگلیسی مقاله Background: While acute rejection and early graft loss rates have decreased substantially over the past four decades, progressive chronic allograft dysfunction (CAD) still remains a common cause of late graft loss in kidney transplant recipients. Objective: This study was conducted to investigate the percentage of natural killer (NK) cell subsets and IL-2, 15 and 18 genes expression in two groups of CAD and well-function graft (WFG) recipients. Methods: 30 renal allograft recipients with biopsy-proven interstitial fibrosis/tubular atrophy (IF/TA) and impaired renal function, and 30 sex- and age-matched WFG patients were enrolled in this study. The percentage of NK cell subsets including NK CD56 bright and NK CD56 dim cells were determined by flowcytometry; IL-2, IL-15, and IL-18 genes expressions were assessed by real-time PCR. Results: Compared to WFG patients, there was a significant (p< 0.05) increase in the percentage of NK CD56 bright cells in CAD patients. However, the difference in percentage of NK CD56 dim cells or CD56 dim / CD56 bright ratio between the studied groups was not significant. In addition, IL-2, 15 and 18 genes expressions were almost similar in CAD and WFG patients. Conclusion: We found higher percentages of NK CD56 bright subset in kidney transplant recipients with CAD without considerable changes in related cytokines’ gene expression, suggesting a possible defect of NK cells maturation in these patients.
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نویسندگان مقاله s assadiasl | s assadiasl


a سپنج نیا | a sepanjnia


b عقیلی | b aghili


m نفر | m nafar


p احمدپور | p ahmadpoor


f پوررضاقلی | f pourrezagholi


m پروین | m parvin


a شهلایی | a shahlaee


mh نیکنام | mh nicknam


a امیرزرگر | a amirzargar


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/313
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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