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International Journal of Organ Transplantation Medicine، جلد ۶، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی The Healing Effect of Adipose-Derived Mesenchymal Stem Cells in Full-thickness Femoral Articular Cartilage Defects of Rabbit
چکیده انگلیسی مقاله Background: Articular cartilage defect can lead to degradation of subchondral bone and osteoarthritis (OA). Objective: To determine the healing effect of transplantation of adipose-derived mesenchymal stem cells (Ad-MSCs) in full-thickness femoral articular cartilage defects in rabbit. Methods: 12 rabbits were equally divided into cell-treated and control groups. In cell-treated group, 2×10 6 cells of third passage suspended in 1 mL of DMEM was injected into articular defect. The control group just received 1 mL of DMEM. Dulbecco’s modified Eagles medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 1% penicillin and streptomycin and 2 mM L-glutamine were used for cell culture. To induce cartilage defect, 4 mm articular cartilage full-thickness defect was created in the knee. For histological evaluation in each group (H&E, safranin-O and toluidine blue), 3 rabbits were sacrificed 4 weeks and 3 animals, 8 weeks after cell transplantation. Results: In cell therapy group post-transplantation, no abnormal gross findings were noticed. Neo-formed tissues in cell-treated groups were translucent with a smooth and intact surface and less irregularity. In cell-treated group after 8 weeks post-transplantation, the overall healing score of experimental knees were superior when compared to other groups. Conclusion: We showed that Ad-MSCs, as an available and non-invasive produced source of cells, could be safely administered in knee osteochondral defects.
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نویسندگان مقاله d مهربانی | d mehrabani


m بابازاده | m babazadeh


n تنیده | n tanideh


s زارع | s zare


s حسین زاده | s hoseinzadeh


s ترابی نژاد | s torabinejad


o کوهی حسین آبادی | o koohi hosseinabadi


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/214
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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