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International Journal of Organ Transplantation Medicine، جلد ۴، شماره ۲، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Dynamic Changes of IFN-γ-producing Cells, TGF-β and Their Predictive Value in Early Outcomes of Renal Transplantation
چکیده انگلیسی مقاله Background: A growing body of evidence demonstrated an immune etiology as well as nonimmune mechanisms for episodes of clinical acute rejection and long-term allograft dysfunction. Objective: To investigate the correlation of IFN-γ-producing cells and TGF-β with incidence of clinical acute rejection in living-related and unrelated kidney allogarft recipients during the first post-transplant year. Methods: This multi-center study was performed on 57 kidney allograft recipients from living-related (n=20) and unrelated (n=37) donors between April 2011 and September 2012 and who were followed prospectively for a mean period of one year. Peripheral blood samples were collected from all patients pre-transplantation and at days 14, 30 and 90 after transplantation; PBMCs were used as responding cells in enzyme-linked immunosorbent spot (ELISPOT) assay to measure the frequency of IFN-γ-producing cells after stimulation with donor lymphocytes. Additionally, TGF-β levels were measured in cell culture supernatants of ELISPOT assay. Results: During the follow-up period, 45 (79%) patients were diagnosed with stable graft function (group A); 12 (21%) experienced clinical acute rejection episodes (group B). The frequency of IFN-γ-producing cells was significantly (p< 0.001) higher in the rejection group in all three times after transplantation. Also, post-transplantation comparison for TGF-β showed a significantly (p< 0.001) higher contents in group A vs. group B. Comparing the post-transplantation levels of TGF-β and mean numbers of IFN-γ-producing cells between groups A and B demonstrated a continuous increment in TGF-β and decreasing frequencies of IFN-γ-producing cells in group A vs . group B. Conclusion: Serial post-transplantation monitoring of IFN-γ-producing donor reactive cells during the first months is a clinically feasible approach for identification of kidney allogarft recipients at risk for ongoing immune-mediated graft damage and later graft loss.
کلیدواژه‌های انگلیسی مقاله Kidney,Allograft,TGF-β,IFN-γ
نویسندگان مقاله f محمدی | f mohammadi


mh نیکنام | mh niknam


m نفر | m nafar


b عین اللهی | b einollahi


b نظری | b nazari


m lessanpezeshki | m lessanpezeshki


ma امیرزرگر | ma amirzargar


g سلگی | g solgi


b نیک بین | b nikbin


aa امیرزرگر | aa amirzargar


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/157
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نوع مقاله منتشر شده Original Articles
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