این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Organ Transplantation Medicine، جلد ۲، شماره ۳، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی The Molecular and Antigenic Tissue Impact of Viral Infections on Liver Transplant Patients with Neonatal Hepatitis
چکیده انگلیسی مقاله Background: Pathogenesis of neonatal hepatitis relates to various underlying causes including viral infections. Both hepatotropic and non-hepatotropic viruses may induce liver failures in infants before birth, during delivery, or shortly after birth. Objectives: The tissue impact of HCMV, HSV, HBV, HCV, and rotavirus and adenovirus infections was evaluated in studied infants with neonatal hepatitis. Methods: The history of viral infections was analyzed in paraffin-embedded biopsy and autopsy tissues of 22 infants with neonatal hepatitis between years 1996 and 2007, retrospectively. The tissue molecular presentation of HBV, HCV, HCMV, HSV, adenovirus, and rotavirus was evaluated by different qualitative simple and nested PCR and RT-PCR protocols. Immunohistochemistry (IHC) method was used for studying the antigenic prevalence of HSV-1, 2; HBV, HCMV and adenovirus infections. Also the laboratory liver indices of all patients with neonatal hepatitis were analyzed. Results: The HBV and HSV genomes were detected in 3 (14%) of 22 infants. The rotavirus and HCV-RNA and also the HCMV-DNA were detected separately in 1 (4%) of 26 paraffin-embedded autopsy and biopsy tissues. The HBV and HSV-1 specific antigens were separately diagnosed in 1 (4%) of 26 neonatal samples by IHC protocols. Also the HSV-2 antigen was seen in 5 (23%) of 22 liver autopsy and biopsy specimens. Co-infections with HCMV, HSV, HBV, HCV, and rotavirus were detected in these infants with hepatitis. Conclusion: Diagnosis of single and mixed molecular and antigenic traces of HCMV, HSV, HBV, HCV and rotavirus underlines the etiologic role of these viruses in clinical pathogenesis of neonatal hepatitis.
کلیدواژه‌های انگلیسی مقاله Neonatal hepatitis,Viral infections,PCR,IHC
نویسندگان مقاله r یعقوبی | r yaghobi


b گرامی زاده | b geramizadeh


s زمانی | s zamani


m راه ساز | m rahsaz


n آذرپیرا | n azarpira


mh کریمی | mh karimi


m آیت اللهی | m ayatollahi


m حسین agdaei | m hossein agdaei


s نیک اقبالیان | s nikeghbalian


a بهادر | a bahador


h صلاحی | h salahi


sa ملک حسینی | sa malek hosseini


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/71
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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