این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Organ Transplantation Medicine، جلد ۲، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism in Renal Transplant Recipients
چکیده انگلیسی مقاله Background: Nitric oxide (NO) is a major mediator in vascular biology, regulating regional blood flow. NO and the enzymes required for its production contribute to ischemia-reperfusion injury. The T-786C functional polymorphism in the promoter region substantially reduces promoter activity of the endothelial nitric oxide synthase (eNOS) gene and compromises endothelial NO synthesis. Objective: To examine the association between T-786C (rs 2070744) single nucleotide polymorphism (SNP) in eNOS gene and the development of acute rejection in renal transplant patients. Methods: 60 renal transplant recipients (30 with episodes of acute rejection (ARs) and 30 without rejection (non-ARs)), between June 2008 and March 2010, were included in this study. The polymorphism was determined by PCR-restriction fragment-length polymorphism analysis. Results: The distribution of the genotypes were TT/TC/CC 60%, 33.4%, 6.6%, and 43%, 46.7%, 13.3% in ARs and non-ARs, respectively (p=0.28). The frequency of T-allele was 76.7% and 66.3%; and for C-allele was 66.6% and 33.3% in ARs and non-ARs, respectively (p=0.09). There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. Conclusion: We could not detect any significant association between polymorphism in T-786C of eNOS gene and the development of acute rejection.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله n آذرپیرا | n azarpira


b گرامی زاده | b geramizadeh


s نیک اقبالیان | s nikeghbalian


a بهادر | a bahador


r یعقوبی | r yaghobi


h کریمی | h karimi


m آیت الهی | m ayatolahi


m aghdai | m aghdai


h صلاحی | h salahi


sa ملک حسینی | sa malek hosseini


j روزبه | j roozbeh


m ثاقب | m sagheb


ga raisjalali | ga raisjalali


a بهزادی | a behzadi


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/66
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات