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International Journal of Organ Transplantation Medicine، جلد ۱، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The Effect of Simvastatin on Lowering Panel Reactive Antibody Titer in Sensitized Dialysis Patients: A Randomized Placebo Controlled Clinical Trial
چکیده انگلیسی مقاله Background: Patients with panel reactive antibodies (PRA) have many difficulties to find a crossmatch-negative kidney for transplantation and are at a higher risk of post-transplantation rejection. Objective: To evaluate the effect of simvastatin on PRA and post-transplant outcome of these sensitized patients. Methods: 82 patients with end-stage renal disease (ESRD) with a PRA ≥25% were evaluated. In a one-year follow-up, the patients were treated with simvastatin. These patients were compared with 82 matched controls receiving placebo tablets. At the end of the second and 12 th month, PRA was rechecked in all patients. Those patients who underwent transplantation continued to take simvastatin six months after transplantation. Serum creatinine levels were checked at monthly intervals post-operation. Results: The mean±SD PRA level at the end of the second month was 36.63%±31.14% and 45.34%±24.36% in cases and controls, respectively (P=0.012). Seven patients in the case group and 10 in the control group were lost to follow-up. The remaining patients continued to take simvastatin for 12 month.The mean±SD PRA level at the end of the 12 th month was 24.02%±31.04% in cases and 43.15%±26.56% in controls (P=0.001). 25 patients underwent renal transplantation and continued to receive simvastatin 6 months after transplantation. These patients were matched with 25 controls treating with placebo. The mean±SD creatinine level 6 months after kidney transplantation was 2.05±1.14 mg/dL and 3.15±1.09 mg/dL in cases and controls consecutively (P=0.02). Conclusion: Simvastatin can be safely used to lower PRA and improve post-transplantation outcomes.
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نویسندگان مقاله j روزبه | j roozbeh


a sattarinezhad | a sattarinezhad


r افشاریانی | r afshariani


a اشراقیان | a eshraghian


محمد مهدی ثاقب | m m sagheb


g raeesjalali | g raeesjalali


s بهزادی | s behzadi


s نیک اقبالیان | s nikeghbalian


m صالحی پور | m salehipour


h صلاحی | h salahi


a بهادر | a bahador


سید علی ملک حسینی | s a malek hosseini


نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/20
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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