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Cell Journal، جلد ۱۹، شماره ۳، صفحات ۳۵۲-۳۶۰
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عنوان انگلیسی VDR and CYP24A1 Expression Analysis in Iranian Relapsing-Remitting Multiple Sclerosis Patients
چکیده انگلیسی مقاله Objective: Multiple sclerosis (MS) is a common disease of the central nervous system which can be initiated by vitamin deficiency. It may also be triggered by enzymes such as CYP24A1 and vitamin D receptor related to vitamin D metabolism. Materials and methods: The expression of vitamin D receptor (VDR) and CYP24A1 in relapsing-remitting MS (RRMS) patients was compared with normal individuals in Iranian population. RNA from whole blood of 50 RRMS patients (HLA-DRB1*15 negative and responders to interferon-beta with a normal vitamin D level) and 50 normal controls were extracted. The level of CYP24A1 and VDR gene expression was measured using quantitative RT-PCR. Results: The RRMS patients manifested a significantly higher expression level of VDR gene than their normal counterparts (P value=0.04). On the other hand, there was a decrease in the expression level of CYP24A1 gene in MS patients which was not statistically significant. Besides, there was no linear correlation between CYP24A1 or VDR expression level, and the risk of Expanded Disability Status Scale of Kurtzke (EDSS); nor were there any significant correlation between expression status of CYP24A1 or VDR genes and duration of the disease. Conclusion: Up-regulation of VDR gene expression is likely to happen in RRMS patients in Iranian population. In this study, we failed to draw an exact CYP24A1 gene expression–phenotype correlation which may be due to limited statistical confirmation as a result of the small sample size and needs more investigation. In fact, although the people taking part in this study had normal levels of vitamin D, the increase in VDR expression levels may perhaps be a response to defect in vitamin D processing; or, despite a increase in VDR expression level, factors such as micro-RNAs could cause their deactivation while an increase in VDR expression level can be seen as a compensatory response. Of course, further studies are needed to identify the mechanism of action of vitamin D and the genes involved in the signaling pathway of this vitamin, particularly VDR and CYP24A1.
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نویسندگان مقاله | Hashem Sadeghi


| Mohammad Taheri


| Elham Sajjadi


| Abolfazl Movafagh


| Shahram Arsang Jang


| Arezou Sayad


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4192
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