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Cell Journal، جلد ۱۹، شماره ۳، صفحات ۴۲۵-۴۳۳
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عنوان انگلیسی Anti-Inflammatory Effects of Curcumin on Insulin Resistance Index, Levels of Interleukin-6, C-Reactive Protein, and Liver Histology in Polycystic Ovary Syndrome-Induced Rats
چکیده انگلیسی مقاله Objective: Curcumin protect the liver against injury and fibrogenesis by suppressing hepatic inflammation, attenuating hepatic oxidative stress, inhibiting hepatic stellate. Non-alcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovary Syndrome (PCOS) are common metabolic disorders. Having low-grade chronic inflammation such as elevated C-Reactive Protein (CRP), Interleukin-6 (IL-6) play a crucial role in PCOS. In this study the therapeutic effect of Curcumin on IL-6, CRP and insulin resistance on liver function in PCOS rats was examined. Materials and methods: In this experimental study, 90 adult female Wistar rats were divided into control, PCOS and curcumin-treated groups. PCOS group was injected subcutaneously with 2 mg estradiol valerate, after 60 days and syndrome Induction, PCOS group was treated with curcumin (100,300 mg/kg BW) for 14 days and anesthetized by chloroform. blood samples and livers were collected for histological and serological evaluation. Data were analyzed using in-stat 3 via one-way ANOVA and P< 0.05 was considered statistically significant. Results: Liver sections and serological analysis showed reduced number of necrotic cells, insulin resistance index, IL-6 and CRP in PCOS rats that were treated with various concentrations of Curcumin. Conclusion: In this study we observed that Curcumin could decrease inflammation of liver by induction of insulin sensitivity and decrease hepatic necrosis, so could be protective against inflammatory state of PCOS.
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نویسندگان مقاله | Shima Mohamadi


| Latifeh Karimzadeh Bardei


| Vida Hojati


| Azita Ghorbani


| Mohammad Nabiuni


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4415
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