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Cell Journal، جلد ۱۹، شماره ۳، صفحات ۴۵۲-۴۶۰
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عنوان انگلیسی Administration of Selenium Decreases Lipid Peroxidation and Increases Vascular Endothelial Growth Factor in Streptozotocin Induced Diabetes Mellitus
چکیده انگلیسی مقاله Objective: The disbalance in the oxidant/antioxidant status plays a pivotal role in diabetes mellitus (DM). Selenium (Se) is a integral component of antioxidant enzyme glutathione peroxidase. Se treatment induces angiogenesis and improves endothelial function through increased expression of vascular endothelial growth factor (VEGF). The aim of this study was to investigate the effect of Se on oxidative stress, VEGF and endothelin 1 (ET1) in DM. Materials and methods: We performed an experimental animal study with 64 adult male Wistar-Albino rats. Rats were divided in the following groups (n=8): C7, C21, C+ Se7, C+ Se21 (control rats) and DM7, DM21, DM+Se7, DM+Se21. Diabetes was induced by streptozotocin (STZ). Three weeks after STZ DM+Se7, DM+Se21 rats were injected with with 0.4 mg/kg/i.p. sodium selenite for 7/21 days. The same dose/duration of Se was administered to the C+Se7, C+Se21 groups. The remaining rats (C7, C21, DM7, DM21) were injected with physiologic saline for 7/21 days. Ferric reducing antioxidant power (FRAP), malondialdehyde (MDA), advanced oxidation protein products (AOPP), and endothelial function markers (VEGF and ET1) in plasma samples were measured. Results: Plasma FRAP (p= 0.002, p= 0.001), AOPP (p= 0.024, p= 0.01), MDA (p= 0.004, p= 0.001), and ET1 (p= 0.028, p= 0.003) levels were significantly increased, VEGF (p= 0.02, p= 0.01) significantly decreased in diabetic rats (DM7, DM21) according to controls (C7, C21). Se administration reversed the increased MDA and the decreased VEGF levels, and lowered plasma glucose levels in diabetic groups (DM+Se7 and DM+Se21) according to controls. There were positive correlations between FRAP-AOPP (r= 0.460), FRAP-ET1 (r= 0.510), AOPP-MDA (r= 0.270), AOPP-ET1 (r= 0.407), and negative correlation between MDA-VEGF (r= -0.314). Conclusion: Oxidative stress was accentuated and endothelial function was impaired in diabetes. Se treatment reduced the lipid peroxidation and hyperglycemia, and through increasing the VEGF levels probably improved the endothelial dysfunction in diabetic rats.
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نویسندگان مقاله | Pervin Vural


| Gulcan Kabaca


| Refia Deniz Firat


| Sevgin Degirmencioglu


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4161
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