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Cell Journal، جلد ۱۹، شماره ۳، صفحات ۴۶۹-۴۷۵
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عنوان انگلیسی Cardio-Protective Role of Gingerol along with Prominent Anti-Diabetic Cardiomyopathy Action in A Streptozotocin-Induced Diabetes Mellitus Rat Model
چکیده انگلیسی مقاله Aim & objective: The diabetic cardiomyopathy (DCM) is characterized as a coronary heart disease which expands during diabetes due to the alteration in the myocardial function and structure. The currentstudy was intended to elucidate the protective effect ofgingerol on DCM in streptozotocin(STZ)induced diabetic mellitus(DM) rat. Material & methods: The animals were distributed into three groups, such as, normal control, DM control and DM+gingerol (10 mg/kg). The body weight of the all group rats was estimated at a regular interval. The myocardial profile, oxidative stress and activities of metabolic enzymes were also scrutinized. The proinflammatory cytokines levels together with cellular protein expression connected with the apoptosis were estimated via western blot. Result: The rats suffered from DCM exhibited the abnormal level of myocardial markers, aberrant metabolic enzymatic activity, elevated concentration of inflammatory factors and enhancement of oxidative stress parameters along with increased cell death apoptosis. Whereas, the rats treated with the gingerol, confirmedprotective effectin the treated rats via improving antioxidant defense system,apoptosis, myocardial dysfunction and inflammation in the cardiac of the DM rats. Conclusion: The current finding suggested the protective effect of gingerol in the treatment of DCM via inhibition of inflammation, cell death and oxidative stress.
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نویسندگان مقاله | Li-Ya Yu


| Wen-Lei Shi


| Xin-Gui Guo


نشانی اینترنتی http://celljournal.org/journal/article/abstract/4509
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