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Iranian Biomedical Journal، جلد ۲۳، شماره ۱، صفحات ۶۳-۷۲
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عنوان انگلیسی The Effects of Lactobacillus casei on Glycemic Response, Serum Sirtuin1 and Fetuin-A Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
چکیده انگلیسی مقاله Background: Type 2 diabetes mellitus (T2DM) is related to the gut microbiota with numerous molecular mechanisms. Modulating the gut microbiota by probiotics could be effective in management of T2DM. The aim of the present trial was to evaluate the effect of Lactobacillus casei on glycemic control and serum sirtuin1 (SIRT1) and fetuin-A in patients with T2DM. Method: Forty patients with T2DM (n = 20 for each group) were divided into intervention (probiotic) and placebo groups. The intervention group received a daily capsule containing 108 cfu of L. casei for eight weeks. The patients in placebo group took capsules containing maltodextrin for the same time duration. Anthropometric measurements, dietary intake questionnaires, and blood samples were collected, and the patients were assessed by an endocrinologist at the beginning and at the end of the trial. Results: Fasting blood sugar, insulin concentration, and insulin resistance significantly decreased in probiotic group compared with placebo group (-28.32 [-50.23 to -6.41], 0.013; -3.12 [-5.90 to -0.35], 0.028; -32.31 [-55.09 to -9.54], 0.007, respectively). Moreover, HbA1c reduced after intervention, but the reduction was not significant (-0.45 [-0.96 to 0.05], 0.077). In comparison with placebo, the L. casei supplementation significantly increased SIRT1 and decreased fetuin-A levels at the end of the trial (0.52 [0.026 to 1.02], 0.040; -17.56 [-32.54 to -2.58], 0.023, respectively).  Conclusions: L. casei supplementation affected SIRT1 and fetuin-A levels in a way that improved glycemic response in subjects with T2DM. Affecting the SIRT1 and fetuin-A levels introduces a new known mechanism of probiotic action in diabetes management.
کلیدواژه‌های انگلیسی مقاله Lactobacillus casei, Probiotics, Type 2 diabetes mellitus
نویسندگان مقاله | Leila Khalili
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


| Beitullah Alipour
Department of Community Nutrition, Faculty of nutrition and food sciences, Tabriz University of Medical Sciences, Tabriz, Iran;


| Mohammad Asghari Jafar-Abadi
Department of statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran;


| Ismail Faraji
Internist, fellow of Endocrinology, Tabriz University of Medical Sciences, Tabriz, Iran;


| Tohid Hassanalilou
Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


| Mehran Mesgari Abbasi
Drug Applied Research Center,Tabriz University of Medical Sciences, Tabriz, Iran


| Elnaz Vaghef-Mehrabany
Department of Nutrition, Biochemistry and Diet Therapy, Faculty of nutrition and food science, Tabriz University of Medical Sciences, Tabriz, Iran


| Mahmood Alizadeh Sani
Department of Food Science and Technology, Faculty of nutrition and food sciences, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-733&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-1041054.pdf
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