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Cell Journal، جلد ۲۱، شماره ۱، صفحات ۳۵-۴۲
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عنوان انگلیسی Downregulation of Extracellular Matrix and Cell Adhesion Molecules in Cumulus Cells of Infertile Polycystic Ovary Syndrome Women With and Without Insulin Resistance
چکیده انگلیسی مقاله Objective: The extracellular matrix (ECM) of cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore gene expression profiles for ECM and cell adhesion molecules in the cumulus cells of polycystic ovary syndrome (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS). Materials and methods: This prospective case-control study enrolled 23 women < 36 years of age that underwent an intracytoplasmic sperm injection (ICSI) program. Patients were subdivided into 3 groups: control (n=8, fertile women with male infertility history), insulin resistant (IR) PCOS (n=7), and insulin sensitive (IS) PCOS (n=8). We compared 84 ECM component and adhesion molecule genes expression by a real-time PCR-based array among groups. Results: Twenty one of the 84 studied genes were differentially expressed among groups, 18 of them with downregulation. Overall comparison of PCOS cases with controls showed downregulation of ECM1, CTNNA1, ITGA5, LAMA3, LAMB1, FN1 and ITGA7 genes. We found upregulation of ADAMTS8 and NCAM1 in IS group compared with controls (P< 0.05). Conclusion: Downregulation of ECM and cell adhesion molecules seem to be related with PCOS. Gene expression profile alterations in cumulus cells of two groups of PCOS patients, IS and IR, seems to be involved in the composition and regulation of ECM during ovulation process. This study highlights the association of ECM gene alteration as a viewpoint for more understanding the etiology of PCOS.
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نویسندگان مقاله | Fatemeh Hassani


| Shahrbanoo Oryan


| Poopak Eftekhari-Yazdi


| Masood Bazrgar


| Ashraf Moini


| Nahid Nasiri


| Ali Sharifi-Zarchi


نشانی اینترنتی http://celljournal.org/journal/article/abstract/5576
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