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Cell Journal، جلد ۲۱، شماره ۱، صفحات ۹۲-۹۸
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عنوان انگلیسی Comparison of The Therapeutic Effect of Syngeneic, Allogeneic, and Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Abortion Rates in A Mouse Model
چکیده انگلیسی مقاله Objective: Mesenchymal stem cells (MSCs), due to their immunomodulatory functions, are an ideal candidate for the treatment of immune related diseases. Recurrent spontaneous abortion (RSA) is one of the most common complications of pregnancy which in many cases is related to the immune system disorders. Our previous study has shown that the abortion rate was decreased following syngeneic MSCs therapy in abortion prone mice. In this study the therapeutic effect of syngeneic, allogeneic, and xenogeneic MSCs were compared in a mouse model of RSA. Materials and methods: MSCs were isolated from adipose tissue of CBA/J, BALB/c mice and human. After characterization, MSCs were injected (IP) In this intervention study, MSCs were isolated from adipose tissue (ASCs) of CBA/J and BALB/c mice and human. After characterization, ASCs were injected (IP) at day 4 of gestation to female CBA/J mice following their mating with DBA/2 male mice. In control group, PBS was injected and CBA/J × BALB/c mating was also used as normal pregnancy control. On day 14.5 of pregnancy, embryo resorption rate was determined.at day 4 of gestation to female CBA/J mice following their mating with DBA/2 male. In control group PBS was injected and CBA/J x BALB/c mating was also used as normal pregnancy control. On day 14.5 of pregnancy embryo resorption rate was determined. Results: The abortion rate significantly decreased following ASCs therapy from syngeneic (6.31%), allogeneic (6.54%), and xenogeneic group (12.36%) compared to ASCs non-treated group (34.4%). There was no statistical difference between ASCs treated group, however syngeneic and allogeneic ASCs reduced abortion rate more efficiently than xenogeneic ASC. Conclusion: The abortion rate was significantly decreased following intraperitoneal administration of ASCs from various donated sources in abortion prone mice. These results indicated that the immunogenicity of allogeneic and xenogeneic ASCs is not a contradictory problem for their therapeutic effects on RSA.
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نویسندگان مقاله | Fatemeh Rezaei


| Seyed Mohammad Moazzeni


نشانی اینترنتی http://celljournal.org/journal/article/abstract/5954
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