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Iranian Journal of Neonatology، جلد ۴، شماره ۲، صفحات ۵-۹
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عنوان انگلیسی Surfactant Administration via Thin Catheter during Spontaneous Breathing: Randomized Controlled Trial in Alzahra hospital
چکیده انگلیسی مقاله Introduction Respiratory distress syndrome (RDS) is a current cause of morbidity in premature infants resulted from surfactant deficiency. The primary aim of this randomized study was to describe the feasibility of early administration of surfactant via a thin catheter during spontaneous breathing (TEC) and compare its outcomes with the InSurE (Intubate, Surfactant, Extubate) procedure Materials and Methods Premature infants with RDS, who were ≤ 32 weeks old and stabilized with nasal continuous positive airway pressure (nCPAP), were randomized to receive surfactant either by the TEC or InSurE technique. Tracheal instillation of 200 mg/kg Curosorf via 5-F catheter during spontaneous breathing under nCPAP was performed in the intervention group (n=38). In the InSurE group (n=40), infants were intubated, received positive pressure ventilation for 30 seconds after surfactant instillation, and placed on nCPAP immediately Results Necrotizing enterocolitis rate was significantly lower in TEC group, than InSurE group, [p< 0.02, RR=0.49, CI=%95(0.39_0.62)]. But rate of other morbidities did not significant difference between two groups. Although Mechanical ventilation duration did not significant different between two groups (p=0.2), but Total CPAP duration was shorter in TEC group, significantly [P< 0.01, RR=8.2, CI=%95 (-37.9_-4.8)]. Need for O2 supplement and mean of total hospital duration was also lower in TEC group, but was not significant, statistically Conclusion The TEC technique is feasible for the treatment of respiratory distress syndrome in infants with very low birth weight and decreases total nCPAP duration, significantly. But Judgment of substitution TEC instead of InSurE as a routine technique need to more studies.
کلیدواژه‌های انگلیسی مقاله RDS, Surfactant, InSurE, Thin Endotracheal Catheterization
نویسندگان مقاله کیوان میرنیا | kayvan mirnia
neonatologist, pediatrics health research center, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محمد حیدرزاده | mohammad heidarzadeh
assistant prof. of neonatology, dept. of pediatrics, tabriz university of medical sciences, director of dept. of neonatal health, ministry of health amp;amp; medical education, tabriz ,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محمد باقر حسینی | mohammad bagher hoseini
associated prof. of neonatology, dept. of pediatrics, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

علیرضا صادق نیا | alireza sadeghnia
assistant prof. of neonatology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فروزان اکرمی | forouzan akrami
master of maternal and neonatal health science, master of public health sdh , dept. of neonatal health, deputy of public health, ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

معصومه بلیلا | masomeh balila
assistant prof. of neonatology, boosher university of medical sciences, boosher,iran


مرتضی قوجازاده | morteza ghojazadeh
phd of physiology, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

فاطمه شفایی | fatemeh shafai
msc of nicu, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

فاطمه رضایی | fatemeh rezaei
msc of nicu, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://ijn.mums.ac.ir/article_1075.html
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