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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۵، صفحات ۵۵۸-۵۶۶
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عنوان انگلیسی Evaluation of acute and sub-acute toxicity of Pinus eldarica bark extract in Wistar rats
چکیده انگلیسی مقاله Objective: Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. Materials and Methods: In the acute study, a single dose of extract (2000 mg/kg) was orally administered and animals were monitored for 7 days. In the sub-acute study, repeated doses (125, 250 and 500 mg/kg/day) of the extract were administered for 28 days and biochemical, hematological and histopathological parameters were evaluated. Results: Our results showed no sign of toxicity and no mortality after single or repeated administration of P. eldarica. The median lethal dose (LD50) of P. eldarica was determined to be higher than 2000 mg/kg. The mean body weight and most of the biochemical and hematological parameters showed normal levels. There were only significant decreases in serum triglyceride levels at the doses of 250 and 500 mg/kg of the extract in male rats (pConclusion: Oral administration of the hydroalcoholic extract of P. eldarica bark may be considered as relatively non-toxic particularly at the doses of 125 and 250 mg/kg.
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نویسندگان مقاله اکرم غدیرخمی | akram ghadirkhomi
department of pharmacology, islamic azad university, shahreza branch, shahreza, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

لیلا صفاییان | leila safaeian
department of pharmacology and toxicology, isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

بهزاد ذوالفقاری | behzad zolfaghari
department of pharmacognosy, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمدرضا آقای قزوینی | mohammad reza aghaye ghazvini
isfahan center of public health training and research, institute of public health research, tehran university of medical science, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

پریسا رضایی | parisa rezaei
department of pathology, seyed-al-shohada hospital, isfahan, iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_6706.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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