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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۵، صفحات ۵۷۸-۵۹۱
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عنوان انگلیسی Effects of flavonoids from Martynia annua and Tephrosia purpurea on cutaneous wound healing
چکیده انگلیسی مقاله Objective: Martynia annua L. (M. annua), (Martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. The leaf paste is used topically on Tuberculosis of the lymphatic glands and wounds of domestic animals. Tephrosia purpurea (T. purpurea), (Fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. This study aimed to evaluate the potential wound healing effects of different fractions ofethanol extract of M. annua leaves and aerial parts of T. purpurea. Materials and Methods: Methanol fraction of M. annua (MAF-C) and ethyl acetate fraction of T. purpurea (TPF-A) were evaluated for healing potential in dead-space and burn wound models. An ointment (5% w/w) of MAF-C and TPF-A, pongamol (0.2 and 0.5% w/w) and luteolin (0.2 and 0.5% w/w) was applied topically twice a day. The effects were compared with Povidone Iodine ointment with respect to protein, collagen content, enzymatic assay and histopathological finding of granuloma tissues. Results: Ethanol extracts of M. annua and T. purpureawere exhibited total flavonoid contents of 126.2 ± 4.69 and 171.6 ± 6.38 mg (quercetin equivalent), respectively. HPLC fingerprinting confirmed the presence of luteolin in M. annua and quercetin in T. purpurea. TPF-A and MAF-C ointments (5% w/w) significantly increases the hydroxyproline and protein contents. Luteolin and pongamol ointments were also found to be effective in both wound models. Conclusion: Our findings suggested that 5% w/w ointment of TPF-A and MAF-C fractions were more effective than isolated flavonoids in wound healing which may be due to synergistic interactions between the flavonoids and other constituents.
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نویسندگان مقاله santram lodhi | santram lodhi
department of pharmaceutical sciences, dr. h. s. gour university, sagar, madhya pradesh, india


avijeet jain | avijeet jain
department of pharmacy rkdf university, bhopal madhya pradesh, india-462033


alok پالیزبان jain | alok pal jain
department of pharmacy, guru ramdas khalsa institute of science amp;amp; technology, kukrikheda, barela, jabalpur m.p. , india


rajesh pawar | rajesh pawar
department of pharmacognosy, vns institute of pharmacy, bhopal, madhya pradesh, india


abhay کومار singhai | abhay kumar singhai
department of pharmaceutical sciences, dr. h. s. gour university, sagar, m.p., 470003. india
نشانی اینترنتی http://ajp.mums.ac.ir/article_6760.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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