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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۴، صفحات ۴۷۶-۴۸۸
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عنوان انگلیسی Anxiolytic-like effect of ethanolic extract of Argemone mexicana and its alkaloids in Wistar rats
چکیده انگلیسی مقاله Objective: Argemone mexicana is a Papaveracea plant; some reports have shown their antibacterial, anti-cancer, sedative and probably anti-anxiety properties. From their aerial parts, flavonoids and alkaloids have been isolated, which are intrinsically related to some actions on the central nervous system. The aim of this study was to evaluate the anxiolytic-like effects of the plant, using its ethanolic extract and alkaloid-enriched extract obtained from fresh leaves. Material and Methods: Phytochemical screening was carried out together with evaluation of antioxidant capacity and the enrichment of alkaloids present in the extract. Subsequently, 100 and 200 mg/kg doses of ethanolic extract and alkaloid-enriched extract (200 µg/kg) were intraperitoneally administered to female Wistar rats, which were exposed to elevated plus maze (EPM) test. Picrotoxin (1 mg/kg), a non-competitive gamma-aminobutyric acid A (GABAA) chloride channel antagonist, was used in experimental procedures to evaluate if this receptor is involved in the anxiolytic-like effects of A. mexicana. To discard motor effects associated with the treatments, the rats were evaluated by the locomotor activity test. Results: Only the ethanolic extract at 200 mg/kg and alkaloid-enriched extract (200 µg/kg) produced anxiolytic-like effects similarly to diazepam 2 mg/kg on EPM test, without affecting locomotor activity. Meanwhile, the administration of picrotoxin blocked anti-anxiety effect of alkaloid-enriched extract of the plant. Conclusion: These results showed that A. mexicana is a potential anxiolytic agent and we suggest that this effect is mediated by the GABAA receptor. These effects are related to the presence of alkaloids.
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نویسندگان مقاله aideé itzel arcos مارتینز | aideé itzel arcos martínez
institute of neuroethology, university of veracruz uv , xalapa-veracruz, mexico


عمر دیوید muñoz muñiz | omar david muñoz muñiz
support services unit in analytical resolution sara , university of veracruz uv , xalapa-veracruz, mexico


میگویل ángel domínguez ortiz | miguel ángel domínguez ortiz
institute of basic sciences icb , university of veracruz uv , xalapa-veracruz, mexico


margarita virginia saavedra vélez | margarita virginia saavedra vélez
institute of neuroethology, university of veracruz uv , xalapa-veracruz, mexico


maribel maribel vázquez hernández | maribel maribel vázquez hernández
support services unit in analytical resolution sara , university of veracruz uv , xalapa-veracruz, mexico


ماریا gabriela alcantara lopez | maria gabriela alcantara lopez
faculty of pharmaceutical and biological chemistry qfb , university of veracruz uv , xalapa-veracruz, mexico
نشانی اینترنتی http://ajp.mums.ac.ir/article_6701.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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