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Avicenna Journal of Phytomedicine، جلد ۶، شماره ۱، صفحات ۶۷-۷۶
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عنوان انگلیسی Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta
چکیده انگلیسی مقاله Objective: Diabetes is an important risk factor for cardiovascular events. The great percent of morbidity in patients with diabetes is due to endothelial dysfunction. The present study investigated the effects of hydroalcholic extract of Nigella sativa (N. sativa) on contractile and dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Materials and Methods: Rats were divided into six experimental groups (control, untreated STZ-diabetic, and N. sativa hydroalcholic extract or metformin-treated diabetic rats). Treated rats received N. sativa extract (100, 200, and 400 mg/kg) or metformin (300 mg/kg) by gavage, daily for 6 weeks. Isolated rat thoracic rings were mounted in an organ bath system then contractile and dilatation responses induced by phenylephrine (PE), acetylcholine (ACh), potassium chloride (KCl), and sodium nitroprusside (SNP) were evaluated in different situations. Results: The lower concentrations of N. sativa seed extract (DE 100 and DE 200) and metformin significantly reduced the contractile responses to higher concentrations of PE (10-6 - 10-5 M) compared to diabetic group (pThe relaxation response to Ach 10-8M, was increased in DE 200 and metformin groups compared to diabetic group (p< 0.05). The relaxation responses to Ach 10-7 - 10-5Mwere significantly higher in all treated groups compared to diabetic group (pConclusion: Chronic administration of N. sativa seed extract has a significant hypoglycemic effect and improves aortic reactivity to vasoconstrictor and vasodilator agents in STZ-induced diabetic rats.
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نویسندگان مقاله عباسعلی عباس نژاد | abbasali abbasnezhad
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سعید نیازمند | saeed niazmand
cardiovascular research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مریم محمودآبادی | maryam mahmoudabady
neurogenic inflammation research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد سوختانلو | mohammad soukhtanloo
department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سید عبدالرحیم رضایی | seyed abdolrahim rezaee
department of immunology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سید مجتبی موسوی | seyed mojtaba mousavi
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_4187.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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