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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۴، صفحات ۳۵۵-۳۶۴
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عنوان انگلیسی Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats
چکیده انگلیسی مقاله Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system. Results: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it. Conclusion: The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.
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نویسندگان مقاله arun کومار | arun kumar
mahavir cancer institute amp;amp; research centre, patna, bihar, india


ranjit کومار | ranjit kumar
mahavir cancer institute amp;amp; research centre, patna, bihar, india


محمد samuir رحمان | mohammad samuir rahman
mahavir cancer institute amp;amp; research centre, patna, bihar, india


محمد asif iqubal | mohammad asif iqubal
mahavir cancer institute amp;amp; research centre, patna, bihar, india


gautam anand | gautam anand
mahavir cancer institute amp;amp; research centre, patna, bihar, india


pintoo کومار niraj | pintoo kumar niraj
mahavir cancer institute amp;amp; research centre, patna, bihar, india


محمد علی | mohammad ali
mahavir cancer institute amp;amp; research centre, patna, bihar, india
نشانی اینترنتی http://ajp.mums.ac.ir/article_4353.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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