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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۲، صفحات ۱۳۸-۱۴۷
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عنوان انگلیسی Effects of ethanol extract of Salvia hydrangea on hepatic and renal functions of streptozotocin-induced diabetic rats
چکیده انگلیسی مقاله Objectives: A wide range of liver and kidney disorders are associated with diabetes and there is a mutual relationship between diabetes and these diseases. Herbal medicine with having abundant ingredients is one of these options. The goal of this study was to compare the effects of alcoholic extract of aerial parts of Salvia hydrangea with glibenclamide on functional tests of liver and kidney in diabetic rats induced by streptozotocin. Materials and Methods: In this study, 35 male Wistar rats were divided into five groups (n= 7 in each group): control, diabetic control, and three experimental diabetic groups. The controls had normal access to water and food, the diabetic control group was given drug solvent and the three experimental groups received ethanol extract of Salvia hydrangea at doses of 100 and 200 mg and glibenclamideat a dose of 10 mg/kg/BW by gavage, respectively. To induce diabetes, a single dose of streptozotocin (60 mg/kg/BW) was injected to rats intraperitoneally. Blood samples were collected at day 21 from all groups and the related blood factors were measured and analyzed. Results: The results showed that the levels of creatinine, urea, aspartate aminotransferase (AST), and fasting blood sugar (FBS) in all diabetic groups increased compared to the control group. In all experimental groups and the group which received glibenclamide,a significant decrease was shown compared to the diabetic group (p< 0.05). Conclusion: The consumption of alcoholic extract of aerial parts of Salvia hydrangea may have beneficial effects on the reduction of diabetic complications by lowering blood sugar without any adverse effects on the kidney and liver tissue.
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نویسندگان مقاله علی زارعی | ali zarei
department of biology, unit of science and research, islamic azad university of damghan, damghan, i.r. iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی دامغان (Islamic azad university of damghan)

غلامحسن واعظی | gholamhassan vaezi
department of biology, unit of science and research, islamic azad university of semnan, semnan, i.r. iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی سمنان (Islamic azad university of semnan)

علی اکبر ملکی راد | ali akbar malekirad
department of biology, payame noor university, i. r. iran

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

محمد عبداللهی | mohammad abdollahi
faculty of pharmacy, pharmaceutical sciences research center, tehran university of medical sciences, tehran, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_3941.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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