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Avicenna Journal of Phytomedicine، جلد ۵، شماره ۲، صفحات ۱۴۸-۱۵۶
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عنوان انگلیسی Effects of aqueous extract of turnip leaf (Brassica rapa) in alloxan-induced diabetic rats
چکیده انگلیسی مقاله Objectives: Turnip leaf has been used in folk medicine of Iran for the treatment of diabetes. However,so far no scientific study has been done to support its use in traditional medicine. The present study was carried out to evaluate the possible hypoglycemic efficacy of aqueous extract of turnip leaf (AETL) in diabetic rats. Materials and Methods: Alloxan-induced diabetic rats were orally treated with AETL at doses of 200 and 400 mg/kg body weight (bw) per day for 28 days. In order to evaluate the anti-diabetic activity, fasting blood glucose concentrations were determined on the 1st, 14th and 29th days. Moreover,at the end of the study, plasma concentrations of total cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), aspartate amino transfarase (AST), and alanine amino transferase (ALT) were measured by the use of standard kits and auto-analyzer. Results:Both doses of AETL significantly decreased (p< 0.001) blood glucose and ALT levels in diabetic rats after 28 days of administration. AETL at both doses decreased (p< 0.05) plasma total cholesterol and LDL-c in diabetic rats, but they significantly decreased (p< 0.05) HDL-c and increased triglycerideand AST levels in a-dose dependent manner. Conclusion: The results showed that AETL has a dose- dependent decrease in the blood glucose in diabetic rats. However,we should not be unaware of adverse effects of AETL on lipid profiles and liver enzymes activity, especially decrease of HDL and increase of TG and AST.
کلیدواژه‌های انگلیسی مقاله Diabetes Mellitus, Alloxan, Brassica rapa
نویسندگان مقاله محمد حسن پور فرد | mohammad hassanpour fard
department of physiology and pharmacology, birjand university of medical sciences bums , birjand, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)

قدرت اله ناصح | ghodratollah naseh
department of general surgery, bums, birjand ,iran


نسیم لطفی | nassim lotfi
department of anatomy, bums, birjand, iran


سید محمود حسینی | seyed mahmoud hosseini
department of biostatistics, bums, birjand, iran


مهران حسینی | mehran hosseini
department of public health, research centre of experimental medicine, bums, birjand, iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_3980.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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