این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۵، شماره ۱، صفحات ۶۲-۶۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Immunomudulatory effects of hydroalcoholic extract of Hypericum perforatum
چکیده انگلیسی مقاله Objective: Hypericum perforatum (St. John's Wort) has long been used in traditional medicine to treat a variety of internal and external ailments. The present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of H. perforatum. Materials and Methods: Twenty male BALB/c-mice were randomly allocated in two equal groups and immunized with sheep red blood cells (SRBCs) and complete Freund’s adjuvant. Mice in the treatment group orally received hydroalcoholic extract of H. perforatum (110 mg/Kg daily) from the beginning of the study which continued for 2 weeks. Results: The data indicated a significant increase in the level of anti-SRBC antibody and simultaneously a significant decrease in the level of cellular immunity, an enhancement in foot pad thickness, in treatment group compared to control group. The level of the respiratory burst in phagocytic cells and the level of lymphocyte proliferation in splenocytes were significantly decreased in the treatment group compared to control group. Moreover, extract caused a significant reduction in the production of pro-inflammatory IL-17 as well as IFN-γ, parallel to increasing the level of IL-6. Conclusions: The hydroalcoholicextract of H. perforatum may be used as a natural source for treatment of immunopathologic conditions.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سید میثم ابطحی فروشانی | seyyed meysam abtahi froushani
assistant professor of immunology, department of microbiology veterinary medicine faculty, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

هادی اسماعیلی گورچین galee | hadi esmaili gouvarchin galee
msc student of immunology, department of microbiology, veterinary faculty, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

مهسا خمیس آبادی | mahsa khamisabadi
student of veterinary medicine, veterinary faculty, urmia university, urmia, iran.

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

بیتا lotfallahzade | bita lotfallahzade
student of veterinary medicine, veterinary faculty, urmia university, urmia, iran.

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_3476.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات