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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۶، صفحات ۴۳۰-۴۳۶
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عنوان انگلیسی Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds
چکیده انگلیسی مقاله Objective: The present study is aimed to investigate in vitro thrombolytic activity of three Bangladeshi medicinal plants Averrhoa bilimbi (Oxalidiaceae), Clerodendrum viscosum (Verbanaceae) and Drynaria quercifolia (Polypodiaceae). Materials and methods: Each the plant was extracted with methanol at room temperature and the concentrated methanolic extracts (MEF) were fractionated by the modified Kupchan partitioning method to render pet-ether soluble fraction (PESF), carbon tetrachloride soluble fraction (CTSF), chloroform soluble fraction (CSF) and aqueous soluble fraction (AQSF). To observe their thrombolytic potential, a prompt and swift method was involved where streptokinase and water were used as positive and negative control, respectively. Result: Among the three plants, AQSF and PESF of D. quercifolia with CTSF of C. viscosum exhibited highest thrombolytic activity by clot lysis of 34.38%, 34.27% and 28.64%, respectively. Among other extracts A. bilimbi, C. viscosun and D.quercifolia showed significant percentage (%) of clot lysis compared to standard streptokinase (41.05%) while the negative control water revealed 3.31 % lysis of clot. Conclusion: From our findings it is observed that all the plants revealed remarkable thrombolytic activity. Therefore, steps should be taken to observe in vivo clot dissolving potential and to isolate active component(s) of these extracts.
کلیدواژه‌های انگلیسی مقاله In vitro, Streptokinase thrombolytic activity, % Clot lysis
نویسندگان مقاله md علی | md. ali
department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh


مرجان حسین | marjan hossain
department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh


jannatul runa | jannatul runa
department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh


md hasanuzzaman | md. hasanuzzaman
department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh


md اسلام | md. islam
department of pharmacy, noakhali science and technology university, sonapur, noakhali- 3814, bangladesh
نشانی اینترنتی http://ajp.mums.ac.ir/article_3226.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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