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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۴، صفحات ۲۵۱-۲۵۹
عنوان فارسی
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عنوان انگلیسی The role for nitric oxide on the effects of hydroalcoholic extract of Achillea wilhelmsii on seizure
چکیده انگلیسی مقاله Objective: Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures.Regarding the central nervous system depressant effects of Achillea wilhelmsii (A. wilhelmsii), as well the effects of the plant on NO, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of A. wilhelmsii on pentylenetetrazole (PTZ)-induced seizures. Materials and Methods: Fifty-six male Wistar rats were divided into 7 groups (n=8 in each group) and treated with (1) normal saline, (2) normal saline before pentylenetetrazole (PTZ, 90 mg/kg), (3-7) A. wilhelmsii extract (100, 200, 400, 800, and 1200 mg/kg) before PTZ. Latency to first minimal colonic seizure (MCS) and the first generalized tonic-clonic seizures (GTCS) as well as the mortality rate were recorded. The brain tissues were then removed for biochemical measurements. Fisher’s exact probability test as well as analysis of variance (ANOVA), followed by Tukey’s test were used for statistical evaluation. Results: Treatment with 100- 1200 mg/kg of the extract did not affect MCS latencies. 400 mg/kg of the extract prolonged GTCS latency (p< 0.001), however, the lower and higher doses were not effective. Nitric oxide metabolites concentrations in the hippocampal tissues of the animals treated with 100, 200, and 400 mg/kg of the extract were increased compared with saline (pConclusion: The present study showed that hydroalcoholic extract of A. wilhelmsii affects NO metabolites in brain tissues as well the severity of seizures in PTZ-induced seizure model.
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نویسندگان مقاله محمود حسینی | mahmoud hosseini
neurocognitive research center, school of medicine, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه هرندی زاده | fatemeh harandizadeh
department of physiology, school of medicine, mashhad university of medical sciences mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سعید نیازمند | saeed niazmand
neurogenic inflammation research center, school of medicine, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد سوختانلو | mohammad soukhtanloo
department of biochemistry, school of medicine, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آزاده faizpour | azadeh faizpour
neurogenic inflammation research center, school of medicine, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مرضیه ghasemabady | marzieh ghasemabady
department of biochemistry, school of medicine, mashhad university of medical sciences, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_2217.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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