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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۴، صفحات ۲۷۶-۲۸۶
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عنوان انگلیسی Effect of hydroalcoholic extract of ginger on the liver of epileptic female rats treated with lamotrigine
چکیده انگلیسی مقاله Objective: Lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. Zingiber officinale Roscoe (ginger) possesses antioxidant properties. In present research, the effect ofhydroalcoholic extract of ginger (HEG) on the liver of lamotrigine-treated epileptic rats was investigated Material and Methods: Forty-eight female Wistar rats were selected and allocated to 8 groups of 6 each. Group 1: Negative controls were treated with normal saline. Group 2: Positive controls were treated with lamotrigine (LTG) (10 mg/kg) daily by gavages for 4 consecutive weeks. Epilepsy was induced in treatment groups by i.p. injection of pentylenetetrazol (PTZ) (40 mg/kg). Group 3: Epileptic group received normal saline (10 ml/kg). Group 4: Epileptic group was treated with LTG (10 mg/kg). Groups 5 and 6: Epileptic groups received HEG (50 and 100 mg/kg). Groups 7 and 8: Epileptic groups received LTG and HEG (50 and 100 mg/kg). At the end of 28 days, blood samples were drawn and their livers were processed for light microscopy. Results: The mean values of TG, CHOL, AST, and ALT activity significantly rose (p< 0.01) in groups 2, 3, and 4, while in rats treated with HEG (groups 5, 6, 7, and 8), the levels of liver enzymes significantly decreased (p< 0.05) compared with epileptic group treated with lamotrigine (group 4). Histopathological changes of liver samples were comparable with respective control. Conclusion: These results suggest that hydroalcoholic extract of ginger improves liver function in lamotrigine-induced hepatotoxicity.
کلیدواژه‌های انگلیسی مقاله Epilepsy, Lamotrigine, Liver, Zingiber officinale, Rat
نویسندگان مقاله آمنه پوررستمی | ameneh poorrostami
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

فرخی فرخی | farah farokhi farokhi
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

رضا حیدری | reza heidari
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_1914.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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