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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۲، صفحات ۱۲۷-۱۳۶
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عنوان انگلیسی Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats
چکیده انگلیسی مقاله Objective: Anti-inflammatory, immuno-modulatory, and antioxidant properties of Moringa oleifera Lam. suggest that it might have beneficial effects on colitis. The present study was performed to investigate the anticolitis effect of Moringa oleifera seeds hydro-alcoholic extract (MSHE) and its chloroform fraction (MCF) on acetic acid-induced colitis in rats. Materials and Methods: Both MSHE and MCF with three increasing doses (50, 100, and 200 mg/kg) were administered orally to separate groups of male Wistar rats, 2 h before ulcer induction (using acetic acid 4%) and continued for 5 days. Prednisolone (4 mg/kg) and normal saline (1 ml/kg) were used in reference and control groups, respectively. All rats were sacrificed 24 h after the last dose (at day 6) and tissue injuries were assessed macroscopically and pathologically. Results: Extracts with three doses mentioned before were effective to reduce weight of distal colon (8 cm) as a marker for inflammation and tissue edema. Three doses of MSHE and two greater doses of MCF (100 and 200 mg/kg) were effective to reduce ulcer severity, area, and index as well as mucosal inflammation severity and extent, crypt damage, invasion involvement, total colitis index, and MPO activity compared with controls. MCF (50 mg/kg) was not significantly effective in reducing evaluated parameters of colitis compared with controls. Conclusion: It is concluded that MSHE and MCF were both effective to treat experimental colitis and this might be attributed to their similar major components, biophenols and flavonoids. Since the efficacy was evident even in low doses of MSHE, presence of active constituents with high potency in seeds is persuasive.
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نویسندگان مقاله محسن میناییان | mohsen minaiyan
department of pharmacology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r.iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

غلامرضا اصغری | gholamreza asghari
department of pharmacognosy, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

دیانا طاهری | diana taheri
department of clinical pathology, school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مژگان سعیدی | mozhgan saeidi
isfahan pharmaceutical sciences research center, isfahan, i. r. iran


سالار نصر اصفهانی | salar nasr esfahani
school of medicine, isfahan university of medical sciences, isfahan, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_1072.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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