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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۲، صفحات ۱۳۷-۱۴۳
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عنوان انگلیسی The effects of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric ulcer in male rats
چکیده انگلیسی مقاله Objective: Gut–brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. Materials and Methods: Gastric ulcer was induced by injection of 20% acetic acid into the subserosal layer in male rats. Rats were randomly assigned into three groups: intact group, gastric ulcer group and Aloe vera group (treatment with Aloe vera following gastric ulcer induction). The acid levels and brain and intestinal water content of each sample were measured eight days after the gastric ulcer induction. Results: Gastric acid levels were significantly decreased in Aloe vera group when compared with gastric ulcer group (p< 0.05). However, there were no differences in acid output between gastric ulcer and Aloe vera groups with intact group. After Aloe vera administration, the amount of brain water content had no difference with intact and gastric ulcer groups (p< 0.05). The duodenal water content in Aloe vera group was significantly reduced compared with intact group (p< 0.05) but gastric ulcer group had no significant difference with intact and Aloe vera group. Conclusions: The administration of Aloe vera has an inhibitory effect on the gastric acid output.
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نویسندگان مقاله زکیه کشاورزی | zakieh keshavarzi
department of physiology, school of medicine, bojnurd university of medical sciences, bojnurd, i. r. iran


طاها محمد رضاپور | taha mohammad rezapour
student research committee, school of medicine, north khorasan university of medical sciences, bojnurd, i. r. iran


مهران وطنچیان | mehran vatanchian
department of physiology, school of medicine, bojnurd university of medical sciences, bojnurd, i. r. iran


محمد زارع حصاری | mohammad zare hesari
student research committee, school of medicine, north khorasan university of medical sciences, bojnurd, i. r. iran


هادی نبی زاده حقیقی | hadi nabizade haghighi
student research committee, school of medicine, north khorasan university of medical sciences, bojnurd, i. r. iran


مصطفی ایزانلو | mostafa izanlu
student research committee, school of medicine, north khorasan university of medical sciences, bojnurd, i. r. iran


مریم صباغیان | maryam sabaghian
department of physiology, north khorasan university of medical sciences, bojnurd, i. r. iran


کاوه شاه ویسی | kaveh shahveisi
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_1909.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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