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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۴، صفحات ۳۴۷-۳۵۵
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عنوان انگلیسی Sesame effects on testicular damage in streptozotocin-induced diabetes rats
چکیده انگلیسی مقاله Objective(s): Reproductive dysfunction is a consequence of diabetes. Diabetes is associated with changes in testicular tissue. Sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin E, and monounsaturated fatty acid (MUFA). The present study investigated the effects of sesame on testis histology and male reproductive parameters in streptozotocin-induced diabetic rats. Materials and Methods: Thirty mature male Wistar rats were randomly divided into three groups, i.e., control (C), diabetic-control (DC), and sesame-treated diabetic rats (SD). Diabetes was induced by a single dose of streptozotocin (65 mg/kg; i.p). The animals were treated by a single intraperitoneal sesame extract injection (100 mg/kg b.w.) once daily for 6 weeks. Results: The biochemical analysis revealed that the diabetes resulted in significant (p< 0.05) reduction in spermiogenesis, testosterone, LH, and FSH levels. Light microscopic analysis showed remarkable (p< 0.05) reduction in STD (seminiferous tubules diameter), SPI (spermatogenesis index) thickness of the epithelium, and significant increase in thickness of the interstitial tissue in the diabetic group compared with the control group. Simultaneous administration of the sesame could fairly up-regulate testosterone, LH, and FSH of the animals in this group. However, some differences were manifested with improved histological features as thickness of the epithelium, seminiferous tubules diameter, and spermatogenesis index. Conclusion: These data demonstrated that sesame significantly improved diabetes complication in rat testis. This study suggested that sesame might have a protective effect against oxidative stress-induced impaired testicular functions in diabetic rats.
کلیدواژه‌های انگلیسی مقاله Diabetes, Sesame, Spermatogenesis, Testis
نویسندگان مقاله فرشته خانشی | fereshteh khaneshi
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

عذرا نصرالهی | ozra nasrolahi
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

شهریار عزیزی | shahriar azizi
department of anatomy, school of medicine, mashhad university, mashhad, i. r. iran


وحید نجاتی | vahid nejati
department of comparative histology and embryology, faculty of veterinary medicine, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_768.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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