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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۴، صفحات ۳۵۶-۳۶۳
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عنوان انگلیسی Hydroalcoholic extract of Crocus sativus effects on bronchial inflammatory cells in ovalbumin sensitized rats
چکیده انگلیسی مقاله Objective: Inflammation is one of the major components of asthma. Our aim was to evaluate the effects of C. sativus extract on total and differential white blood cells (WBC) count in lung lavage fluid (LLF) of ovalbumin-sensitized rats. Materials and Methods: Forty rats were divided into five groups (n = 8 for each group) as control (C), sensitized with injection and inhalation of ovalbumin (OA) alone (S), and three groups of sensitized and treated with different doses of C. sativus extract (S+50EX, S+100EX, and S+200EX groups). Total and differential WBC counts of LLF were evaluated in control, sensitized, and treated sensitized groups. Results: Total WBC count, neutrophil, and eosinophil percentage in LLF were increased in sensitized animals compared with the control group (p< 0.001). Treatment of sensitized animals with all doses of the extract significantly reduced WBC number and the percentage of neutrophil and eosinophil compared with the sensitized animals (p< 0.01–0.001). Conclusion: According to these results, the extract of C. sativus could be effective on alleviating lung inflammatory cells specially eosinophils in lung lavage of sensitized animals which may indicate a preventive effect of this plant on lung inflammation in asthma.
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نویسندگان مقاله مریم محمودآبادی | maryam mahmoudabady
applied physiology research center and department of physiology, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علی نعمتی | ali neamati
department of biology, faculty of science, mashhad branch, islamic azad university, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سمیه وثوقی | somayyeh vosooghi
department of biology, payame noor university, boshruyeh, south khorasan, i. r. iran

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

حیدر آقابابا | heydar aghababa
department of biology, faculty of science, arsanjan branch, islamic azad university, i. r. iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ajp.mums.ac.ir/article_767.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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