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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۲، صفحات ۱۱۲-۱۲۵
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عنوان انگلیسی Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves
چکیده انگلیسی مقاله Objective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO-) as well as inhibition of total ROS generation, and assessment of reducing power were used to evaluate antioxidant potential of MPBL. Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (p< 0.05) increase in pain threshold in hot plate method whereas significantly (p< 0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose-dependent manner. The same ranges of doses of MPBL caused significant (p< 0.05) inhibition of carrageenan-induced paw edema after 4 h in a dose-dependent manner. In DPPH, ONOO-, and total ROS scavenging method, MPBL showed good antioxidant potentiality with the IC50 value of 16.33±1.02, 25.16±0.61 , and 41.72±0.48 µg/ml, respectively with a significant (p< 0.05) good reducing power. Conclusion: The findings of the study suggested that MPBLhas strong analgesic, anti-inflammatory, and antioxidant effects, conforming the traditional use of this plant for inflammatory pain alleviation to its antioxidant potentiality.
کلیدواژه‌های انگلیسی مقاله Analgesic, Antioxidant, Anti-inflammatory, Piper betle
نویسندگان مقاله بدرول عالم | badrul alam
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


فهیما akter | fahima akter
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


ناهده پروین | nahida parvin
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


rashna شرمین pia | rashna sharmin pia
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


شرمین akter | sharmin akter
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


jesmin چاودری | jesmin chowdhury
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


kazi sifath e جهان | kazi sifath e jahan
department of pharmacy, atish dipankar university of science amp;amp; technology, dhaka, bangladesh


ekramul haque haque | ekramul haque haque
department of pharmacy, university of rajshahi, rajshahi, bangladesh
نشانی اینترنتی http://ajp.mums.ac.ir/article_16.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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