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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۲، صفحات ۱۳۵-۱۴۲
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عنوان انگلیسی Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mecenchymal stem cells
چکیده انگلیسی مقاله Objective: Osteoporosis or silent disease is a major bone disorder in elderly women in current century. Estrogen has an important role in osteogenesis and prevention of bone fractures. Hormone replacement therapy (HRT) is usually accompanied by such effects as breast and ovary cancers. Thus, there is an increasing demand for replacement with plant phytoestrogens. This study is focused on determining the effects of Foeniculum vulgare extract on proliferation and osteogenesis progress in human mesenchymal stem cells. Material and Methods: Human mesenchymal stem cells were isolated and treated with different amount of plant extracts (0.5 to 100 µg/ml). Extract cytotoxicity was measured using MTT assay. The alkaline phosphatase enzyme activity was measured to evaluate the differentiation progress. Results: Results of MTT assay and alkaline phosphatase activity showed that Foeniculum vulgare extract, at range of 5 to 50 µg/ml, may positively affect cell proliferation and mineralization. The most proliferation and enzyme activity were seen with dose of 5 µg/ml. Conclusions: Foeniculum vulgare has been used in Iranian folk medicine for many years. Our in vitro study showed that Foeniculum vulgare extract has osteoprotective effects.
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نویسندگان مقاله زهرا محمودی | zahra mahmoudi
department of biotechnology, faculty of new technologies and energy engineering, shahid beheshti university, tehran, i. r. iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

مسعود سلیمانی | masoud soleimani
department of hematology, faculty of medical sciences, tarbiat modares university, tehran, i. r. iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

عباس سعیدی | abbas saidi
department of biotechnology, faculty of new technologies and energy engineering, shahid beheshti university, tehran, i. r. iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

غلامرضا خمیسی پور | gholamreza khamisipour
department of hematology, school of medicine, boushehr university of medical science, boushehr, i. r. iran


آرزو azizsoltani | arezoo azizsoltani
department of biotechnology, faculty of agriculture, bu-ali sina university, hamedan, i. r. iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_3.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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