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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۲، صفحات ۱۴۳-۱۵۱
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عنوان انگلیسی Histophatologic changes of lung in asthmatic male rats treated with hydro-alcoholic extract of plantago major and theophylline
چکیده انگلیسی مقاله Objective: Plantago major (P. major) is one of the medicinal crops in the world which has therapeutic properties for treatment of respiratory and gastrointestinal diseases. Theophylline is commonly used for the treatment of respiratory diseases. In this study, we investigated the protective effects of hydro-alcoholic extract of P. majoron lung in asthmatic male rats. Materials and Methods: 32 male adult rats were randomly divided into 4 groups: The control group (C) received normal saline; Asthma (A) group received a normal diet; Asthma group treated with Theophylline (200 mg/kg b.w.) (T); Asthma group which received p.major (100 mg/kg b.w.) (P). Asthma was induced by citric acid, 0.1 mg in form of spraying. The injection of P.major extract and theophylline was administered intraperitoneally for four weeks. At the end of the treatment, all of the rats were sacrificed and lungs were taken out, fixed, and stained with H&E, toluidine blue, and PAS, then histological studies were followed with light microscope. Results: Results showed that, in asthmatic group, the mean number of mast cells was significantly increased (p< 0.05). Thickness of alveolar epithelium and accumulation of glycoprotein in airways was increased. Moreover, in some of alveolar sac hemorrhaging was observed. Administration of p.major extract in asthmatic rats restored these changes towards normal group. Conclusion: The present study revealed that P. major compared with theophylline, has a protective effect on lung in asthmatic rats.
کلیدواژه‌های انگلیسی مقاله Asthma, Lung, Male Rats, Plantago major, Theophylline
نویسندگان مقاله فرح فرخی | farah farokhi
department of biology, faculty of science, urmia university, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

فرشته خانشی | fereshteh khaneshi
department of biology, faculty of science, urmia university, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_4.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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