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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۱، صفحات ۸۲-۹۰
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عنوان انگلیسی Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats
چکیده انگلیسی مقاله Objective: Barberry root extract contains various alkaloids that are considered as antioxidants. Beneficial effect of aqueous extract of Berberis integerrima root (AEBIR) was evaluated for renal function in diabetic rats induced by STZ. Material and Methods: Diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. Diabetic rats were randomly grouped and treateddaily with AEBIR and glibenclamide by gavage for 42 days. After 6 weeks of study, all the rats were sacrificed and some biochemical parameters of serum and urine were measured and their kidneys tissues were processed for light microscopy. Results: Streptozotocin induced a significant rise in fasting blood glucose, serum creatinine, blood urea nitrogen, urine glucose, urine protein, urine albumin, and water intake and a significant decrease in body weight, serum protein, urine urea, and urine creatinine. There was a significant restoration of these parameters to near normal after administration of the AEBIR and also by glibenclamide (0.6 mg/kg bw). The activity of the extract at dose of 500 mg/kg in all parameters except blood glucose and urine glucose was more than that of the standard drug, glibenclamide (0.6 mg/kg, p.o.). Histopathological changes of kidney samples were comparable with respective control. Conclusion: These results suggested that aqueous extract of Berberis Integerrima root improves renal dysfunction in streptozotocin-induced diabetic rats through controlling blood glucose and renal protective effects.
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نویسندگان مقاله رضا حیدری | reza heidari
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

وحید نجاتی | vahid nejati
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

مینو ایلخانی پور | minoo ilkhanipoor
department of biology, faculty of science, urmia university, urmia, i. r. iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ajp.mums.ac.ir/article_13.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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