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World Journal of Plastic Surgery، جلد ۴، شماره ۲، صفحات ۱۰۱-۱۰۹
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عنوان انگلیسی Platelet-Rich Fibrin Promotes an Accelerated Healing of Achilles Tendon When Compared to Platelet-Rich Plasma in Rat
چکیده انگلیسی مقاله BACKGROUND Autologous platelet concentrate has been used to improve the function and regeneration of injured tissues. Tendinopathies are common in clinical practice, although long-term treatment is required. On the basis of lead time, we compared the effect of using platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in repairing rat Achilles tendon. METHODS The effectiveness of using PRP and PRF was evaluated after 14 and 28 postoperative days by histological analysis. The quantification of collagen types I and III was performed by Sirius red staining. Qualitatively, the data were verified with hematoxylin-eosin (H&E) staining. RESULTS In Sirius red staining, no significant treatment differences were found between groups. Statistical difference was observed only between PRP (37.2% collagen) and the control group (16.2%) 14 days after treatment. Intra-groups compared twice showed a difference for collagen I (27.8% and 47.7%) and III (66.9% and 46.0%) in the PRF group. The control group showed differences only in collagen I (14.2% and 40.9%) and no other finding was observed in the PRP group. In H&E staining, PRF showed a better cellular organization when compared to the other groups at 28 days. CONCLUSION Our study suggests that PRF promotes accelerated regeneration of the Achilles tendon in rats, offering promising prospects for future clinical use.
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نویسندگان مقاله franciele dietrich | franciele dietrich
porto alegre


gustavo lançanova duré | gustavo lançanova duré
porto alegre


caroline peres klein | caroline peres klein
porto alegre


vinícius faccin bampi | vinícius faccin bampi
porto alegre


alexandre vontobel padoin | alexandre vontobel padoin
porto alegre


vinícius duval da سیلوا | vinícius duval da silva
porto alegre


jefferson braga سیلوا | jefferson braga silva
porto alegre
نشانی اینترنتی http://www.wjps.ir/browse.php?a_code=A-10-111-1&slc_lang=en&sid=en
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