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World Journal of Plastic Surgery، جلد ۴، شماره ۱، صفحات ۲۹-۳۵
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عنوان انگلیسی The Healing Effect of Curcumin on Burn Wounds in Rat
چکیده انگلیسی مقاله BACKGROUND Burns are still considered one of the most devastating conditions in emergency medicine affecting both genders and all age groups in developed and developing countries, resulting into physical and psychological scars and cause chronic disabilities. This study was performed to determine the healing effect of curcumin on burn wounds in rat. METHODS Seventy female Sprague-Dawley 180-220 g rats were randomly divided into 5 equal groups. Groups of A-C received 0.1, 0.5 and 2% curcumin respectively and Group D, silver sulfadiazine ointment. Group E was considered as control group and received eucerin. After 7, 14 and 21 days of therapy, the animals were sacrificed and burn areas were macroscopically examined and histologically were scored. RESULTS Administration of curcumin resulted into a decrease in size of the burn wounds and a reduction in inflammation after 14th days. Reepithelialization was prominent in groups A-C while more distinguishable in group C. In group C, epidermis exhibited well structured layers without any crusting. There were spindle shaped fibroblasts in fascicular pattern, oriented parallel to the epithelial surface with eosinophilic collagen matrix. CONCLUSION Curcumin as an available and inexpensive herbal was shown be a suitable substitute in healing of burn wounds especially when 2% concentration was applied.
کلیدواژه‌های انگلیسی مقاله Burn, Curcumin, Wound, Healing, Rat
نویسندگان مقاله داود مهربانی | davood mehrabani
stem cell and transgenic technology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مجتبی فرجام | mojtaba farjam
department of medical pharmacology, school of medicine, fasa university of medical sciences, fasa, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی فسا (Fasa university of medical sciences)

بیتا گرامی زاده | bita geramizadeh
organ transplant research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نادر تنیده | nader tanideh
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مسعود امینی | masood amini
laparascopy research center, department of surgery, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدرضا پنجه شاهین | mohammad reza panjehshahin
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://www.wjps.ir/browse.php?a_code=A-10-53-6&slc_lang=en&sid=en
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